What is INOSgest?
Polycystic Ovary Syndrome (PCOS)
- May not have enough hormones needed to ovulate, instead, the ovaries can develop many small cysts, and have high levels of androgens (Male sex hormone).
- Can have missed or irregular menstrual periods, excess hair growth, acne, infertility, and weight gain.
- Either obese or have insulin resistance (where muscles and fat are unable to utilize insulin properly), leading to reduced insulin-mediated glucose metabolism and increased levels of circulating insulin in the body that may cause higher androgen levels.
Composition of INOSgest:
Inositol has been renamed the “fertility molecule”. Gynecologists are increasingly recommending inositol-based supplements for women with polycystic ovarian syndrome and for women who want to become pregnant. This is because recent studies have shown how regular use of these supplements has a high level of effectiveness and above all the absence of side effects.
Inositol has a positive effect on ovarian function and is useful for correcting endocrine-metabolic disorders related to polycystic ovary syndrome, such as hyperandrogenism, hyperglycemia, and increased insulin resistance. Inositol is a molecule that is found in different forms, but only two of these have shown from clinical studies to be insulin mediators and therefore useful for treating ovarian polycystosis: Myo-inositol (MI) and D-chiroinositol (DCI).
MYO-INOSITOL (MI) and D-CHIRO INOSITOL (DCI)
- Among the nine inositol stereoisomers, MYO-INOSITOL(MI) and D-CHIRO INOSITOL (DCI) are the most important inositol from a biological point of view.
- Myo-Inositol & D-Chiro-Inositol are second messengers in the insulin signal transduction, acting as Insulin Sensitizers.
- MI is involved in the cellular up-take of glucose
- DCI stimulates the oxidative and non-oxidative metabolism of glucose.
- given the importance of dosage on the effectiveness of each inositol species, the ratio between MI and DCI may be less important than the absolute concentrations of either MI or DCI
- a given combination should include at least 300–1500 mg DCI and 2–4 g MI. (1)
- The Ratio 5:1 of Myo-Inositol & D-Chiro-Inositol has been shown to be effective in improving the clinical symptoms of PCOS in women, reducing insulin resistance and improving the hormone pattern.
- This 5:1 ratio has been shown to be safe as it applies no changes on Liver enzymes (aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase).
Folic Acid:
The simultaneous intake of MI and folic acid improves the Oocyte quality.
Manganese:
The simultaneous intake of DCI and manganese helps to reduce insulin resistance.
| Components | For daily intake (1 sachet) | %NRV*/dose |
| Myo-inositol | 2000 mg | – |
| D-chiro-inositol | 400 mg | – |
| Folic acid | 400 µg | 200% |
| Manganese | 10 mg | 500% |
INOSgest Clinical Uses:
- Polycystic Ovary Syndrome (PCOS):(2)
- Irregular Periods.
- Excess Androgen Production.
- Developing ovarian Cysts.
- Infertility.(3)
- Gestational Diabetes:
- develops during pregnancy and usually disappears after giving birth.
- Visceral Obesity:(4)
- The accumulation of fatty acids in the blood and on the vesicular walls can lead to:
- High levels of Cholesterol in the blood.
- High blood pressure.
- Heart disease.
- The accumulation of fatty acids in the blood and on the vesicular walls can lead to:
